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1.
Klinicka Mikrobiologie a Infekcni Lekarstvi ; 28(4):116-128, 2022.
Article in Slovak | GIM | ID: covidwho-20239861

ABSTRACT

Overcoming infection with coronavirus disease 2019 (COVID-19) can lead to the persistence of various symptoms in some patients. The complex of symptoms causally related to severe acute respiratory coronavirus 2 infection is called post-COVID syndrome. One of the most common respiratory complications is pulmonary fibrosis, especially after critical course of the disease. In some patients, ho-wever, only the peripheral airways are affected by the air-trapping seen on high-resolution computed tomography scans. Less common respiratory complications include sarcoidosis and pneumatoceles. This narrative review summarizes current knowledge about pulmonary involvement as part of post-COVID syndrome.

2.
Ceska a Slovenska Psychiatrie ; 119(2):63-67, 2023.
Article in Czech | EMBASE | ID: covidwho-20233335

ABSTRACT

The COVID-19 is associated not only with symptoms of the acute phase, but in some patients some symptoms persist even after overcoming it, we are talking about the so-called post-COVID syndrome. The aim of our work was to identify factors influencing the level of anxiety in patients with this syn-drome. In total, data were obtained from 404 patients, anxiety levels were assessed using the Beck Anxiety Inventory (BAI). The file con-tained 143 men and 261 women, in the age range of 19-90 years. The average BAI value was 13.2 Most often, patients experienced a mild course of covid-19 infection. According to our results, the severity of the COVID-19 infection itself and the presence of comorbid somatic disease have not effect on the BAI value, on the contrary, hospitalization turned out to be a significant factor. Hospitalized patients had a statistically significantly lower level of anxiety than those who experienced this disease at home. Patients with a pathological level of anxiety were significantly younger and, when comparing gender, there were significantly more anxiety in women. The con-nection between the presence of pulmonary post-inflammatory changes on the chest X-ray and the degree of anxiety was not proven, but a statistically significant trend was found.Copyright © 2023, Czech Medical Association J.E. Purkyne. All rights reserved.

4.
Casopis Lekaru Ceskych ; 161(7-8):321-324, 2022.
Article in Czech | Scopus | ID: covidwho-2260388

ABSTRACT

Extracorporeal membrane oxygenation is the highest form of resuscitation care in management of patients with respiratory failure. In the case of acute respiratory distress syndrome, the veno-venous setting is more often used. ECMO support enables, in case of lung function failure, to obtain the necessary time for the onset of the causal treatment effect or is used as a bridge to transplantation Mortality of the patients varies according to the underlying cause and presence of risk factors (e.g., age, complications or comorbid diseases). The onset of the COVID-19 pandemic has led to a significant increase in the need for ECMO. The quality of life of patients after ECMO is significantly reduced, but most patients do not experience permanent disability. © 2022, Czech Medical Association J.E. Purkyne. All rights reserved.

5.
European Respiratory Journal Conference: European Respiratory Society International Congress, ERS ; 60(Supplement 66), 2022.
Article in English | EMBASE | ID: covidwho-2282243

ABSTRACT

Introduction: Despite the growing number of studies on COVID-19, interpreting the data and extracting meaning from these data is challenging. Method(s): We used a multivariate patient similarity network (PSN) approach to analyse ~85 immune (cellular and humoral) and ~70 clinical features in 250 prospectively recruited patients 4-8 weeks after a SARS-CoV-2 diagnostic PCR. Result(s): Our multivariate analysis identified a minimal immune signature (CD69+CD4+ T-lymphocytes, CTLA-4+ Tlymphocytes and immature B-lymphocytes) that was strongly associated with disease severity and manifested even 4-8 weeks after COVID-19. Visualisation of clinical and laboratory parameters in patient clusters detected by PSN showed that a history of severe COVID-19 was associated with less frequent anosmia/ageusia and higher levels of IgM and IgG 4-8 weeks after COVID-19 compared with mild disease. Conclusion(s): Ours study reveals the relationship between immune profiles and severity of COVID-19, showing that more severe COVID-19 is typical lower proportion on immature B cells and cytotoxic T- lymphocytes. Our study demonstrates the benefits of implementing multivariate data-mining approaches for interpreting complex datasets, not only relating to COVID-19.

6.
Vnitrni Lekarstvi ; 67(8):485-488, 2021.
Article in Czech | Scopus | ID: covidwho-1614622

ABSTRACT

Pneumatocele is a cavity, which may develop rarely as a complication of pneumonia. It is more common in patients requiring ventilation support. After COVID-19 pneumonia, there are only several case reports described. Our case report is about a male patient without any serious commorbities. The patient had bilateral multiple pneumatocele which have formed in postacute phase of moderate course of COVID-19. Other possible causes have been exluded by a complex examination. During the follow-up there was a clear gradual spontaneous resorption of the finding. The patient is still in very good clinical condition. © 2021, SOLEN s.r.o.. All rights reserved.

7.
Ceska a Slovenska Neurologie a Neurochirurgie ; 84(4):347-352, 2021.
Article in Czech | EMBASE | ID: covidwho-1457793

ABSTRACT

Aim: Smell disorders are frequent symptoms of COVID-19 disease. This systematic review covers the pathophysiology, diagnostics, prognostic significance, and treatment of COVID-19 related smell disorders. Methods: The articles were selected in accordance with the PRISMA guidelines. The inclusion criteria were: 1. peer-reviewed publications;2. studies on human subjects;3. studies published in English or Czech;and 4. used filters: meta-analysis/systematic review/randomized controlled trial. The exclusion criteria were: 1. abstracts from conferences;2. commentaries;and 3. inclusion of subjects younger than 18 years. The databases PubMed and Web of Science were searched. Using the search term “anosmia OR smell loss OR smell disorders OR dysosmia OR parosmia AND COVID-19”, 157 papers were selected for analysis, with 109 being ruled out based on the exclusion criteria. The full texts and their references were obtained and studied, and the references meeting the inclusion criteria were also included in this review, leading to a total of 68 papers selected for the review. Results: Approximately 60% of patients with COVID-19 disease present with smell disorders. Most studies agree anosmia appears more frequently in the mild course of the disease. The inflammation and demyelination of the olfactory nerve fibres probably play a key role in the pathogenesis. Damage to the supporting cells of the olfactory epithelium may also play an important role. Olfactory disorder may persist over a varying period of time after the resolution of the acute phase of COVID-19. Olfactory training seems to be beneficial in the treatment. The data regarding the efficacy of topical corticosteroids are inconsistent. No other drugs have yet demonstrated a clinical effect. Conclusion: Loss of smell is a common accompanying symptom in mostly mild forms of COVID-19. Olfactory training seems to be effective in treating this dysfunction. Pharmacotherapy (including local and systemic corticosteroids) has not yet proven effective.

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